►𝐉𝐨𝐢𝐧 𝐓𝐡𝐢𝐬 𝐂𝐡𝐚𝐧𝐧𝐞𝐥 𝐓𝐨 𝐆𝐞𝐭 𝐀𝐜𝐜𝐞𝐬𝐬 𝐓𝐨 𝐏𝐞𝐫𝐤𝐬 :- https://bit.ly/2RQHvTN
►𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐭𝐡𝐞 𝐌𝐞𝐝𝐯𝐢𝐳𝐳 𝐚𝐩𝐩 𝐮𝐬𝐢𝐧𝐠 𝐭𝐡𝐞 𝐛𝐞𝐥𝐨𝐰 𝐥𝐢𝐧𝐤 👇👇👇👇 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 👇👇👇👇
►𝐀𝐧𝐝𝐫𝐨𝐢𝐝 :- https://bit.ly/3ansFKq
📌𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦 :-
https://www.instagram.com/drgbhanuprakash
Pyruvate dehydrogenase complex – steps, regulation, and inhibitors
Pyruvate dehydrogenase complex deficiency results in impaired conversion of pyruvate to acetyl-CoA, reduced production of citrate, and thus an impaired TCA cycle, leading to severe energy deficits (especially in the CNS). Long-term treatment includes a ketogenic diet (high fat, low carbohydrate, glucogenic amino acids, e.g. valine) and cofactor supplementation with thiamine and lipoic acid.
The five cofactors of the pyruvate dehydrogenase complex: Tender (Thiamine) Loving (lipoic acid) Care (CoA) For (FAD) Nancy (NAD+).
Arsenic inhibits lipoic acid, thereby preventing the production of acetyl-CoA and inhibiting the TCA cycle!
www.medvizz.com
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